SCHEMBL7358995

SCHEMBL7358995

O=c1cc(O)c2c(o1)CCCCCC2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 5/20 0.44
KDM4E B2RXH2 8/20 0.43
LMNA P02545 1/20 0.43
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C19 P33261 1/20 0.41
MAOB P27338 1/20 0.39
ALDH1A1 P00352 6/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
HPGD P15428 4/20 0.38
HSD17B10 Q99714 4/20 0.38
TSHR P16473 3/20 0.38
GLA P06280 3/20 0.38
GAA P10253 3/20 0.38
CASP1 P29466 3/20 0.38
CASP7 P55210 3/20 0.38
MAPK1 P28482 3/20 0.37
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37
CA12 O43570 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13598105 0.98 MAOA (0.45) MAOAKDM4ELMNACYP1A2CYP3A4
SCHEMBL17861313 0.75 MAOA (0.59) MAOAKDM4ELMNACYP3A4CYP2C19
SCHEMBL20888324 0.73 MAOA (0.45) MAOAKDM4EMAOBALDH1A1SMN1; SMN2
SCHEMBL17844933 0.73 CA12 (0.34) KDM4ELMNACYP3A4ALDH1A1HPGD
SCHEMBL17844923 0.69 MEN1 (0.46) MAOAKDM4ECYP1A2CYP2C19MAOB
SCHEMBL20871939 0.68 MAOA (0.41) MAOAKDM4ELMNAMAOBALDH1A1
SCHEMBL20871940 0.68 MAOA (0.41) MAOAKDM4ELMNAMAOBALDH1A1
SCHEMBL17847583 0.67 ERN1 (0.36) KDM4ELMNACYP2C19AKR1B1MCL1
SCHEMBL8927692 0.67 CYP1A2 (0.44) MAOACYP1A2CYP3A4CYP2C19MAOB
SCHEMBL8926941 0.67 MAOA (0.43) MAOAKDM4EMAOBALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0758327-A1 PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 1997-02-19 EP claimed
EP-0682663-B1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS UPJOHN CO (US) 2001-04-18 EP disclosed
US-6169181-B1 HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY 2001-01-02 US disclosed
EP-0758327-A1 PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 1997-02-19 EP disclosed
WO-1995030670-A2 PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 1995-11-16 WO disclosed
WO-1994018188-A1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS THE UPJOHN COMPANY (US) 1994-08-18 WO disclosed