Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.60 |
| ▸ | PDE4A | P27815 | 10/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | PDE1A | P54750 | 1/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362578 | 0.89 | PDE4D (0.74) | KMT2AMEN1ALDH1A1PKMPDE4D | |
| SCHEMBL7363154 | 0.88 | PDE4D (0.61) | KMT2AMEN1ALDH1A1PKMPDE4D | |
| SCHEMBL7357750 | 0.88 | LMNA (0.68) | ALDH1A1PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7332928 | 0.86 | PDE4D (0.79) | KMT2AMEN1ALDH1A1PKMPDE4D | |
| SCHEMBL7361962 | 0.85 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7363473 | 0.84 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361165 | 0.84 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361861 | 0.84 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7358204 | 0.84 | PDE4D (0.56) | KMT2AMEN1ALDH1A1PKMPDE4D | |
| SCHEMBL7357453 | 0.84 | PDE4D (0.60) | PKMPDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | claimed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |