Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 9/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13754285 | 0.82 | HTT (0.65) | HTTCTSSPKMSMN1; SMN2CAPN1 | |
| SCHEMBL27579548 | 0.82 | HTT (0.53) | HTTCTSSPKMSMN1; SMN2CTSK | |
| SCHEMBL7359850 | 0.78 | MEN1 (0.53) | CTSSSMN1; SMN2CTSKRAB9AALDH1A1 | |
| SCHEMBL11637808 | 0.78 | HTT (0.62) | HTTCTSSPKMSMN1; SMN2NPC1 | |
| SCHEMBL4037754 | 0.77 | MEN1 (0.44) | CTSSPKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL4044696 | 0.77 | MEN1 (0.44) | CTSSPKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL6801263 | 0.76 | CTSS (0.69) | HTTCTSSPKMSMN1; SMN2CAPN1 | |
| SCHEMBL7027854 | 0.76 | CTSS (0.69) | HTTCTSSPKMSMN1; SMN2CAPN1 | |
| SCHEMBL6802863 | 0.76 | CTSS (0.69) | HTTCTSSPKMSMN1; SMN2CAPN1 | |
| SCHEMBL13584807 | 0.75 | HTT (0.54) | HTTCTSSPKMSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |