Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312971 | 1.00 | CHEK2 (0.54) | CHEK2HCRTR1HCRTR2PRMT5LTA4H | |
| SCHEMBL7359533 | 0.92 | PRMT5 (0.58) | CHEK2HCRTR1HCRTR2PRMT5KDM4E | |
| SCHEMBL6609250 | 0.92 | CHEK2 (0.56) | CHEK2HCRTR1HCRTR2PRMT5KDM4E | |
| SCHEMBL4319616 | 0.89 | ALOX5AP (0.50) | PRMT5LTA4HKLK7 | |
| SCHEMBL4317022 | 0.89 | ALOX5AP (0.50) | PRMT5LTA4HKLK7 | |
| SCHEMBL4317028 | 0.89 | ALOX5AP (0.50) | PRMT5LTA4HKLK7 | |
| SCHEMBL7324862 | 0.88 | CHEK2 (0.58) | CHEK2HCRTR1HCRTR2PRMT5LTA4H | |
| SCHEMBL7330394 | 0.88 | LTA4H (0.56) | HCRTR1HCRTR2LTA4HKDM4EMEN1 | |
| SCHEMBL7446645 | 0.87 | CHEK2 (0.52) | CHEK2HCRTR1HCRTR2PRMT5NPC1 | |
| SCHEMBL7399721 | 0.86 | CHEK2 (0.61) | CHEK2HCRTR1HCRTR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926708-B1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2014-06-18 | — | — | EP | disclosed |
| EP-1926708-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Chemistry, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007040682-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2007-04-12 | — | — | WO | disclosed |
| EP-0674514-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013291-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1994-06-23 | — | — | WO | disclosed |