Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 12/20 | 0.70 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.70 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.70 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.70 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.70 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.70 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358466 | 0.84 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7353297 | 0.82 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7356856 | 0.80 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7355016 | 0.80 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7358332 | 0.78 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7351990 | 0.77 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7356851 | 0.77 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7349798 | 0.77 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7355669 | 0.76 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7359877 | 0.75 | GABRG2 (0.68) | GABRG2GABRB3GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156761-A | Substituted tetralone derivatives for enhancing cognition | MERCK SHARPE & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |