Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5285515 | 0.76 | EPHX1 (0.41) | EPHX1IDO1NOS3NOS1NOS2 | |
| SCHEMBL10585977 | 0.76 | NPSR1 (0.47) | IDO1NOS3NOS1NOS2L3MBTL1 | |
| SCHEMBL1615641 | 0.74 | EPHX1 (0.40) | EPHX1IDO1NOS3NOS1NOS2 | |
| SCHEMBL17251292 | 0.74 | L3MBTL1 (0.42) | EPHX1L3MBTL1CYP2C19PPARGPPARA | |
| SCHEMBL9574339 | 0.74 | TSHR (0.42) | EPHX1IDO1NOS3NOS1NOS2 | |
| SCHEMBL10566452 | 0.74 | EPHX1 (0.47) | EPHX1CA12CA1CA2CA9 | |
| SCHEMBL2171639 | 0.74 | TSHR (0.42) | EPHX1IDO1NOS3NOS1NOS2 | |
| SCHEMBL6954426 | 0.74 | PPARG (0.49) | EPHX1IDO1L3MBTL1CYP2C19PPARG | |
| SCHEMBL3294142 | 0.72 | PPARG (0.47) | EPHX1IDO1L3MBTL1CYP2C19PPARG | |
| SCHEMBL13491150 | 0.71 | EPHX1 (0.56) | EPHX1L3MBTL1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722321-A4 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | UNIV FLORIDA STATE (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0722321-A1 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5470834-A | Metalloproteinase enzyme inhibitors for arthritis, rheumatism and cancers | FLORIDA STATE UNIVERSITY (US) | 1995-11-28 | — | — | US | disclosed |
| WO-1995009620-A1 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1995-04-13 | — | — | WO | disclosed |