Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553711 | 1.00 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL7420770 | 0.86 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4553843 | 0.86 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7355719 | 0.85 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11 | |
| Morpholine SCHEMBL4553714 | 0.83 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL5639854 | 0.81 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL6171037 | 0.80 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5640788 | 0.79 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5639664 | 0.74 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11 | |
| Morpholine SCHEMBL7419803 | 0.74 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995003297-A1 | IMIDAZOLES FOR TREATING CYTOKINE MEDIATED DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-02 | — | — | WO | disclosed |