Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL4553714 | 0.91 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| Morpholine SCHEMBL4553844 | 0.84 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| Morpholine SCHEMBL4553334 | 0.79 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| Morpholine SCHEMBL7990935 | 0.74 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL7360193 | 0.74 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4553711 | 0.74 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6171878 | 0.69 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL6583245 | 0.69 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| Morpholine SCHEMBL7382870 | 0.69 | ALOX5 (0.40) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5639236 | 0.68 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995003297-A1 | IMIDAZOLES FOR TREATING CYTOKINE MEDIATED DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-02 | — | — | WO | disclosed |