Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KLK3 | P07288 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362708 | 0.85 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10MAPK1PDE4A | |
| SCHEMBL7359732 | 0.71 | GPBAR1 (0.43) | KDM4EALDH1A1HSD17B10MAPK1PDE4A | |
| SCHEMBL7360296 | 0.68 | PDE4A (0.57) | KDM4EALDH1A1HSD17B10MAPK1MEN1 | |
| SCHEMBL5214099 | 0.63 | PDE4A (0.49) | KDM4EALDH1A1HSD17B10MAPK1PDE4A | |
| SCHEMBL7360976 | 0.63 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10MAPK1PDE4A | |
| SCHEMBL8603220 | 0.62 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10MAPK1PDE4A | |
| SCHEMBL29496946 | 0.61 | MEN1 (0.56) | KDM4EALDH1A1HSD17B10MAPK1MEN1 | |
| SCHEMBL5797361 | 0.61 | MEN1 (0.56) | KDM4EALDH1A1HSD17B10MAPK1MEN1 | |
| Formaldehyde SCHEMBL28904777 | 0.60 | ERN1 (0.55) | KDM4EALDH1A1HSD17B10MAPK1MEN1 | |
| SCHEMBL8707308 | 0.60 | RAB9A (0.69) | KDM4EALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | claimed |
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |
| WO-1996036611-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |