Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 6/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359732 | 0.76 | GPBAR1 (0.43) | KDM4EALDH1A1MAPTTDP1PDE4A | |
| SCHEMBL7362708 | 0.72 | KDM4E (0.47) | KDM4EALDH1A1MAPTTDP1PDE4A | |
| SCHEMBL8603220 | 0.68 | KDM4E (0.46) | KDM4EALDH1A1MAPTTDP1PDE4A | |
| SCHEMBL5214099 | 0.68 | PDE4A (0.49) | KDM4EALDH1A1MAPTTDP1PDE4A | |
| SCHEMBL7366204 | 0.67 | KDM4E (0.45) | KDM4EALDH1A1MAPTTDP1PDE4A | |
| SCHEMBL3757147 | 0.65 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL16797504 | 0.63 | MAPK1 (0.81) | KDM4EALDH1A1MAPTTDP1TSHR | |
| SCHEMBL4169902 | 0.63 | GPBAR1 (0.69) | KDM4EALDH1A1MAPTTSHRMAPK1 | |
| SCHEMBL7362713 | 0.63 | PDE4A (0.63) | KDM4EALDH1A1MAPTTDP1PDE4A | |
| SCHEMBL27996488 | 0.63 | MAPK1 (0.68) | ALDH1A1MAPTPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | claimed |
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |
| WO-1996036611-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |