SCHEMBL7360407

SCHEMBL7360407

COc1ccc(C(=O)O)c2c1OC(C)(C)C2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 4/20 0.46
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 2/20 0.43
LMNA P02545 2/20 0.43
HSD17B10 Q99714 1/20 0.43
MAPT P10636 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
IDO1 P14902 1/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40
PDE4D Q08499 2/20 0.39
PDE4A P27815 1/20 0.39
PDE4B Q07343 1/20 0.39
PDE4C Q08493 1/20 0.39
KMT2A Q03164 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
CDC25B P30305 1/20 0.38
NOD1 Q9Y239 1/20 0.37
HSP90AA1 P07900 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5722811 0.88 KDM4E (0.54) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL8940054 0.88 FFAR4 (0.44) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL183890 0.87 FFAR4 (0.44) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL8068920 0.87 FFAR4 (0.43) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL5723240 0.86 MAPT (0.52) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL5723158 0.86 PDE4D (0.49) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL6031384 0.85 FFAR4 (0.51) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL3452752 0.84 FFAR4 (0.46) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL7360394 0.82 FFAR4 (0.46) FFAR4KDM4EALDH1A1LMNAHSD17B10
SCHEMBL7356280 0.82 KDM4E (0.40) FFAR4KDM4EALDH1A1LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0772610-B9 DIHYDROBENZOFURANES BYK GULDEN LOMBERG CHEM FAB (DE) 2001-07-25 EP disclosed
EP-0772610-B1 DIHYDROBENZOFURANES BYK GULDEN LOMBERG CHEM FAB (DE) 2000-10-04 EP disclosed
US-6121274-A PHOSPHODIESTERASE INHIBITOR FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-09-19 US disclosed
EP-0772610-A1 DIHYDROBENZOFURANES Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1997-05-14 EP disclosed
WO-1996003399-A1 DIHYDROBENZOFURANES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1996-02-08 WO disclosed