SCHEMBL7360394

SCHEMBL7360394

COc1ccc(OC(=O)O)c2c1OC(C)(C)C2

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 4/20 0.46
LMNA P02545 2/20 0.40
PDE4D Q08499 2/20 0.39
PDE4A P27815 1/20 0.39
PDE4B Q07343 1/20 0.39
PDE4C Q08493 1/20 0.39
KMT2A Q03164 1/20 0.39
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 1/20 0.37
HSD17B10 Q99714 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
NOD1 Q9Y239 1/20 0.35
CASP1 P29466 1/20 0.34
CASP7 P55210 1/20 0.34
CTSA P10619 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7358392 0.87 FFAR4 (0.44) FFAR4LMNAPDE4DPDE4APDE4B
SCHEMBL7360479 0.87 FFAR4 (0.43) FFAR4LMNAPDE4DPDE4APDE4B
SCHEMBL9214485 0.82 LMNA (0.43) FFAR4LMNAKMT2AALDH1A1NPC1
SCHEMBL7360407 0.82 FFAR4 (0.46) FFAR4LMNAPDE4DPDE4APDE4B
SCHEMBL7353933 0.82 FFAR4 (0.35) FFAR4LMNAKMT2AKDM4EALDH1A1
SCHEMBL5722811 0.79 KDM4E (0.54) FFAR4LMNAPDE4DPDE4APDE4B
SCHEMBL8940054 0.79 FFAR4 (0.44) FFAR4LMNAKMT2AKDM4EALDH1A1
SCHEMBL183890 0.78 FFAR4 (0.44) FFAR4LMNAPDE4DPDE4APDE4B
SCHEMBL8068920 0.78 FFAR4 (0.43) FFAR4LMNAPDE4DPDE4APDE4B
SCHEMBL5723240 0.78 MAPT (0.52) FFAR4LMNAPDE4DPDE4AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0772610-B9 DIHYDROBENZOFURANES BYK GULDEN LOMBERG CHEM FAB (DE) 2001-07-25 EP disclosed
EP-0772610-B1 DIHYDROBENZOFURANES BYK GULDEN LOMBERG CHEM FAB (DE) 2000-10-04 EP disclosed
EP-0772610-A1 DIHYDROBENZOFURANES Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1997-05-14 EP disclosed
WO-1996003399-A1 DIHYDROBENZOFURANES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1996-02-08 WO disclosed