Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.42 |
| ▸ | PDE4A | P27815 | 5/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15753781 | 0.86 | PDE4D (0.53) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL1616464 | 0.86 | PDE4D (0.53) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL14164833 | 0.86 | PDE4D (0.53) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL30362076 | 0.86 | PDE4D (0.53) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL6858821 | 0.85 | PDE4D (0.45) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL3550785 | 0.85 | PDE4D (0.48) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL8890126 | 0.81 | PDE4D (0.45) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6865440 | 0.80 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL15763184 | 0.80 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14458154 | 0.80 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |