Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 7/20 | 0.45 |
| ▸ | PTAFR | P25105 | 7/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890131 | 0.82 | PDE4A (0.43) | PDE4DPTAFRPDE4ACYP11B1CYP11B2 | |
| SCHEMBL30362076 | 0.82 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1616464 | 0.82 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL15753781 | 0.82 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14164833 | 0.82 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3550785 | 0.81 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7360805 | 0.81 | PDE4B (0.42) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8889715 | 0.80 | PTAFR (0.40) | PDE4DPTAFRPDE4ACYP11B1CYP11B2 | |
| SCHEMBL8889710 | 0.78 | PDE4D (0.67) | PDE4DPTAFRPDE4ACYP11B1CYP11B2 | |
| SCHEMBL6858821 | 0.77 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |