Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
| ▸ | CPB1 | P15086 | 1/20 | 0.30 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175344 | 0.77 | NPC1 (0.40) | NPC1RAB9AKMT2ATBXAS1CPB1 | |
| SCHEMBL6809047 | 0.75 | NPC1 (0.45) | NPC1RAB9AKMT2ATBXAS1 | |
| SCHEMBL8138463 | 0.73 | KMT2A (0.44) | NPC1RAB9AKMT2ATBXAS1 | |
| SCHEMBL27352543 | 0.72 | — | — | |
| SCHEMBL28312345 | 0.72 | NPC1 (0.40) | NPC1RAB9AKMT2ATBXAS1 | |
| SCHEMBL7194692 | 0.72 | NPC1 (0.36) | NPC1RAB9AKMT2ATBXAS1 | |
| SCHEMBL28044670 | 0.71 | GSR (0.43) | NPC1RAB9AKMT2ACPB1CPB2 | |
| SCHEMBL10336338 | 0.71 | PAOX (0.42) | — | |
| SCHEMBL573387 | 0.70 | — | — | |
| SCHEMBL29045186 | 0.70 | NPC1 (0.38) | NPC1RAB9AKMT2ATBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722321-A4 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | UNIV FLORIDA STATE (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0722321-A1 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1996-07-24 | — | — | EP | disclosed |
| WO-1995009620-A1 | SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1995-04-13 | — | — | WO | disclosed |