Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355267 | 0.78 | TSHR (0.41) | ALDH1A1TSHRMAPTSMN1; SMN2LMNA | |
| SCHEMBL5359894 | 0.78 | ALDH1A1 (0.72) | ALDH1A1TSHRFDPSHPGDPOLB | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL28147472 | 0.74 | ALDH1A1 (0.92) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| SCHEMBL6228567 | 0.74 | ALDH1A1 (0.66) | ALDH1A1TSHRFDPSHPGDPOLB | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL5308959 | 0.74 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL1330962 | 0.74 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL25202 | 0.74 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL29364994 | 0.74 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| SCHEMBL2714465 | 0.73 | ALDH1A1 (0.70) | ALDH1A1TSHRFDPSHPGDPOLB | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL29624454 | 0.72 | ALDH1A1 (0.96) | ALDH1A1TSHRFDPSHPGDAOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |