Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 5/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360296 | 0.83 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7359664 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4338217 | 0.76 | HTR6 (0.65) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL4330189 | 0.74 | PDE4D (0.50) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL7360978 | 0.74 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7358727 | 0.73 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8601386 | 0.72 | AKR1C3 (0.64) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL13669265 | 0.72 | GAK (0.54) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL7366201 | 0.71 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL4333431 | 0.71 | NOD2 (0.47) | PDE4APDE4BPDE4CPDE4DHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | claimed |
| WO-1996036611-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |
| WO-1996036611-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |