Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.67 |
| ▸ | PDE4A | P27815 | 13/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352652 | 0.92 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7352658 | 0.92 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7361578 | 0.92 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7356965 | 0.88 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL71331 | 0.87 | PDE4D (0.65) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL7336558 | 0.86 | PDE4D (0.64) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL28371430 | 0.83 | PDE4D (0.65) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL15595689 | 0.82 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL71682 | 0.82 | PDE4B (0.58) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL7359488 | 0.82 | PDE4D (0.48) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |