Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.71 |
| ▸ | PDE4A | P27815 | 13/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.59 |
| ▸ | CA6 | P23280 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | TPMT | P51580 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15595689 | 0.94 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4CCA12 | |
| SCHEMBL7359837 | 0.92 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CCA12 | |
| SCHEMBL7360996 | 0.92 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CCA12 | |
| SCHEMBL7361406 | 0.92 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CCA12 | |
| SCHEMBL28846183 | 0.90 | PDE4B (0.70) | PDE4DPDE4APDE4BPDE4CCA12 | |
| SCHEMBL7361355 | 0.88 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1028427 | 0.87 | PDE4B (0.80) | PDE4DPDE4APDE4BPDE4CCA12 | |
| SCHEMBL30009845 | 0.87 | PDE4B (0.80) | PDE4DPDE4APDE4BPDE4CCA12 | |
| SCHEMBL2586121 | 0.86 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CCA12 | |
| SCHEMBL17908087 | 0.86 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |