Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 14/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619795 | 0.83 | KCNJ11 (0.41) | KCNJ11ABCC9P2RX7 | |
| SCHEMBL8620014 | 0.83 | KCNJ11 (0.48) | KCNJ11ABCC9NAMPTP2RX7 | |
| SCHEMBL7353566 | 0.82 | KCNJ11 (0.46) | KCNJ11ABCC9P2RX7 | |
| SCHEMBL7349705 | 0.80 | KCNJ11 (0.44) | KCNJ11ABCC9P2RX7 | |
| SCHEMBL9425856 | 0.79 | KCNJ11 (0.57) | KCNJ11ABCC9 | |
| SCHEMBL7361551 | 0.79 | TACR3 (0.40) | — | |
| SCHEMBL7361549 | 0.79 | TACR3 (0.40) | — | |
| SCHEMBL7349440 | 0.77 | ABCC9 (0.58) | KCNJ11ABCC9NAMPTP2RX7 | |
| SCHEMBL7359994 | 0.73 | KCNJ11 (0.49) | KCNJ11ABCC9P2RX7 | |
| SCHEMBL8619737 | 0.73 | KCNJ11 (0.45) | KCNJ11ABCC9P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741708-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020579-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-03 | — | — | WO | claimed |
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |