Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.64 |
| ▸ | METAP1 | P53582 | 6/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362176 | 0.90 | METAP2 (0.58) | METAP2METAP1TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7360639 | 0.89 | METAP2 (0.58) | METAP2METAP1TDP1L3MBTL1 | |
| SCHEMBL7354412 | 0.89 | METAP2 (0.61) | METAP2METAP1TDP1L3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7356761 | 0.88 | METAP2 (0.60) | METAP2METAP1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7359630 | 0.87 | METAP2 (0.71) | METAP2METAP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7355975 | 0.87 | METAP2 (0.61) | METAP2METAP1TAS1R3TAS1R1 | |
| SCHEMBL7353356 | 0.87 | METAP2 (0.56) | METAP2METAP1TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7359061 | 0.86 | METAP2 (0.60) | METAP2METAP1TSHRTAS1R3TAS1R1 | |
| SCHEMBL7359902 | 0.86 | METAP2 (0.60) | METAP2METAP1TDP1L3MBTL1 | |
| SCHEMBL7362128 | 0.86 | METAP2 (0.56) | METAP2METAP1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |