Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 15/20 | 1.00 |
| ▸ | METAP1 | P53582 | 8/20 | 1.00 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7353187 | 0.99 | METAP2 (0.98) | METAP2METAP1P2RX7HDAC8 | |
| SCHEMBL7353362 | 0.89 | METAP2 (0.80) | METAP2METAP1P2RX7 | |
| Hydrochloric Acid SCHEMBL7509007 | 0.88 | METAP2 (0.79) | METAP2METAP1P2RX7 | |
| SCHEMBL7350315 | 0.87 | METAP2 (0.77) | METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7362199 | 0.86 | METAP2 (0.76) | METAP2METAP1 | |
| SCHEMBL14984990 | 0.86 | METAP2 (0.75) | METAP2METAP1P2RX7HDAC8CNR1 | |
| SCHEMBL7362502 | 0.84 | METAP2 (0.73) | METAP2METAP1 | |
| SCHEMBL17367862 | 0.84 | METAP2 (0.72) | METAP2METAP1P2RX7HDAC8CNR1 | |
| Hydrochloric Acid SCHEMBL7359098 | 0.84 | METAP2 (0.72) | METAP2METAP1 | |
| SCHEMBL12022074 | 0.83 | METAP2 (0.71) | METAP2METAP1P2RX7HDAC8CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | claimed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |
| US-6242494-B1 | ANGIOGENESIS INHIBITORS, ANTITUMOR AGENTS, DIABETIC RETINOPATHY, AND ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES | 2001-06-05 | — | — | US | disclosed |
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |