Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.55 |
| ▸ | KLK7 | P49862 | 2/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.49 |
| ▸ | CTSS | P25774 | 4/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9223452 | 0.93 | CTSS (0.53) | KLK5KLK7CTSSSYKPPARA | |
| SCHEMBL16574592 | 0.90 | KLK5 (0.57) | KLK5KLK7CACNA1BCTSSSYK | |
| SCHEMBL23374042 | 0.87 | KLK7 (0.49) | KLK5KLK7CACNA1BCTSSSYK | |
| SCHEMBL25715928 | 0.87 | PPARA (0.56) | KLK5KLK7CACNA1BCTSSSYK | |
| SCHEMBL4370045 | 0.86 | KLK5 (0.65) | KLK5KLK7CACNA1BCTSSSYK | |
| SCHEMBL7308756 | 0.86 | MAPT (0.50) | KLK5KLK7CTSSSYKPPARA | |
| SCHEMBL9217565 | 0.86 | MAPT (0.50) | KLK5KLK7CTSSSYKPPARA | |
| SCHEMBL3817109 | 0.84 | PPARA (0.55) | KLK5KLK7CACNA1BCTSSSYK | |
| SCHEMBL1517760 | 0.84 | PPARA (0.55) | KLK5KLK7CACNA1BCTSSSYK | |
| SCHEMBL16290229 | 0.84 | PPARA (0.57) | KLK5KLK7CTSSSYKPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |