Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361748 | 0.83 | FFAR1 (0.46) | NLRP3FOLH1GPR34FFAR1MAOB | |
| SCHEMBL28851016 | 0.83 | PSMB5 (0.54) | PSMB5 | |
| SCHEMBL28851015 | 0.83 | PSMB5 (0.54) | PSMB5 | |
| SCHEMBL7527410 | 0.81 | FFAR1 (0.48) | NLRP3GPR34FFAR1MAOBLMNA | |
| SCHEMBL5043134 | 0.79 | NLRP3 (0.53) | NLRP3FOLH1FFAR1PIN1MAOB | |
| SCHEMBL19803700 | 0.79 | NLRP3 (0.53) | NLRP3FOLH1FFAR1PIN1MAOB | |
| SCHEMBL2822759 | 0.78 | DPP7 (0.52) | NLRP3FOLH1PIN1MAOBLMNA | |
| SCHEMBL8954810 | 0.78 | DPP7 (0.52) | NLRP3FOLH1PIN1MAOBLMNA | |
| SCHEMBL6164203 | 0.78 | DPP7 (0.52) | NLRP3FOLH1PIN1MAOBLMNA | |
| SCHEMBL21016636 | 0.78 | NLRP3 (0.46) | NLRP3FOLH1FFAR1PIN1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942544-A | α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |