Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370079 | 0.86 | PDE4A (0.56) | PDE4APDE4DPDE4CPDE4BKAT2B | |
| SCHEMBL9375241 | 0.84 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BCHRNB4 | |
| SCHEMBL7369501 | 0.81 | PDE4A (0.63) | PDE4APDE4DPDE4CPDE4B | |
| SCHEMBL7361971 | 0.81 | PDE4A (0.60) | PDE4APDE4DPDE4CPDE4BCHRNB4 | |
| SCHEMBL7360386 | 0.80 | PDE4D (0.58) | PDE4APDE4DPDE4CPDE4BCHRNB4 | |
| SCHEMBL7362749 | 0.78 | PDE4A (0.56) | PDE4APDE4DPDE4CPDE4BCHRNB4 | |
| SCHEMBL9379510 | 0.77 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL9375249 | 0.76 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL6636364 | 0.74 | PDE4A (0.71) | PDE4APDE4DPDE4CPDE4BRXFP1 | |
| SCHEMBL9379516 | 0.74 | PDE4A (0.57) | PDE4APDE4DPDE4CPDE4BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |