Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360386 | 0.86 | PDE4D (0.58) | PDE4APDE4DPDE4CPDE4BMAPT | |
| SCHEMBL7370135 | 0.85 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BOPRM1 | |
| SCHEMBL9375254 | 0.84 | PDE4A (0.63) | PDE4APDE4DPDE4CPDE4BMAPT | |
| SCHEMBL7369501 | 0.84 | PDE4A (0.63) | PDE4APDE4DPDE4CPDE4BMAPT | |
| SCHEMBL7360388 | 0.82 | PDE4D (0.66) | PDE4APDE4DPDE4CPDE4BMAPT | |
| SCHEMBL9375241 | 0.80 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BMAPT | |
| SCHEMBL9375249 | 0.80 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9379510 | 0.80 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7361965 | 0.78 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BCHRNB4 | |
| SCHEMBL7359713 | 0.76 | PDE4A (0.75) | PDE4APDE4DPDE4CPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |