Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 7/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357586 | 0.83 | HTR3A (0.52) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL7358583 | 0.81 | HTR3A (0.59) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL7358591 | 0.81 | HTR3A (0.59) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL30037019 | 0.80 | HTR3A (0.58) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL10436140 | 0.80 | HTR3A (0.67) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL7359887 | 0.75 | HTR3A (0.55) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL7362878 | 0.74 | HTR3A (0.56) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL2228533 | 0.73 | HTR3A (0.69) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL7292105 | 0.73 | HTR3A (0.69) | HTR3ACYP2C9CYP2C19HTR3EHTR3B | |
| SCHEMBL2228529 | 0.73 | HTR3A (0.69) | HTR3ACYP2C9CYP2C19HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723103-A | ALTERED 5-HT-3 OR NEUROTRANSMITTER RECEPTOR FUNCTION | VANDERBILT UNIVERSITY (US) | 1998-03-03 | — | — | US | disclosed |
| WO-1996017630-A9 | SUBSTITUTED BENZAMIDES AND RADIOLIGAND ANALOGS AND METHODS OF USE | — | 1996-08-08 | — | — | WO | disclosed |