Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | IDE | P14735 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9376329 | 0.79 | MAPT (0.44) | MEN1POLBKMT2AKDM4EMAPK1 | |
| SCHEMBL9375260 | 0.77 | PDE4A (0.50) | CAMKK2MKNK1MKNK2RAB9AHPGD | |
| Terephthalic Acid SCHEMBL1649598 | 0.74 | MAPT (0.64) | CAMKK2MKNK1MKNK2RAB9AMEN1 | |
| SCHEMBL6873637 | 0.70 | KDM4E (0.56) | CAMKK2MKNK1MKNK2MAP2K4RAB9A | |
| SCHEMBL10325337 | 0.69 | TTR (0.56) | CAMKK2MKNK1MKNK2MAP2K4RORC | |
| SCHEMBL3554044 | 0.69 | TRPV1 (0.61) | CAMKK2MKNK1MKNK2MAP2K4KDM4E | |
| SCHEMBL3874091 | 0.69 | TRPV1 (0.56) | CAMKK2MKNK1MKNK2RORCKDM4E | |
| SCHEMBL1222172 | 0.69 | MKNK1 (0.55) | CAMKK2MKNK1MKNK2RAB9AEGFR | |
| SCHEMBL14422898 | 0.68 | PTGS1 (0.59) | CAMKK2MKNK1MKNK2MAP2K4RAB9A | |
| Hydrochloric Acid SCHEMBL3086577 | 0.68 | TRPV1 (0.59) | CAMKK2MKNK1MKNK2MAP2K4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |