Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | BAD | Q92934 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14886474 | 0.81 | TRPV1 (0.57) | TRPV1KDM4ESMN1; SMN2MAP2K4ALDH1A1 | |
| SCHEMBL6873637 | 0.81 | KDM4E (0.56) | MKNK1MKNK2KDM4ETDP1CAMKK2 | |
| SCHEMBL3554044 | 0.79 | TRPV1 (0.61) | TRPV1MKNK1MKNK2KDM4ETDP1 | |
| SCHEMBL3874091 | 0.79 | TRPV1 (0.56) | TRPV1MKNK1MKNK2KDM4ETDP1 | |
| SCHEMBL29604199 | 0.79 | FEN1 (0.43) | TRPV1KDM4ETDP1HSD17B10DHODH | |
| SCHEMBL2639667 | 0.79 | FEN1 (0.43) | TRPV1KDM4ETDP1HSD17B10DHODH | |
| SCHEMBL3881337 | 0.79 | TRPV1 (0.65) | TRPV1MAP2K4MAPK1MAPK6RORC | |
| SCHEMBL28479998 | 0.78 | TRPV1 (0.47) | TRPV1KDM4EALDH1A1ATM | |
| SCHEMBL14422898 | 0.78 | PTGS1 (0.59) | MKNK1MKNK2KDM4ETDP1CAMKK2 | |
| Hydrochloric Acid SCHEMBL3086577 | 0.78 | TRPV1 (0.59) | TRPV1MKNK1MKNK2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748610-B2 | Compounds as TRPV1 antagonists, pharmaceutical compositions and medical uses thereof | FL THERAPEUTICS LLC (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748610-B2 | Compounds as TRPV1 antagonists, pharmaceutical compositions and medical uses thereof | FL THERAPEUTICS LLC (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748610-B2 | Compounds as TRPV1 antagonists, pharmaceutical compositions and medical uses thereof | FL THERAPEUTICS LLC (US) | 2014-06-10 | — | — | US | disclosed |
| US-20120184509-A1 | Compounds as TRVP1 Blockers, Pharmaceutical Compositions and Medical Uses Thereof | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2012-07-19 | — | — | US | disclosed |
| US-20120184509-A1 | Compounds as TRVP1 Blockers, Pharmaceutical Compositions and Medical Uses Thereof | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2012-07-19 | — | — | US | disclosed |
| US-20120184509-A1 | Compounds as TRVP1 Blockers, Pharmaceutical Compositions and Medical Uses Thereof | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184509-A1 | Compounds as TRVP1 Blockers, Pharmaceutical Compositions and Medical Uses Thereof | TRPV1, TRPV4, TRPV3 | TTR 1854/4885TRPV1 1/4885MKNK1 2052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.