Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847651 | 0.94 | KDM4E (0.65) | KDM4EKMT2APIM1PDE4DMETAP2 | |
| SCHEMBL11121278 | 0.89 | KDM4E (0.90) | KDM4EKMT2APIM1PDE4DMMP2 | |
| SCHEMBL171491 | 0.87 | KDM4E (1.00) | KDM4EKMT2APIM1PDE4DMMP2 | |
| SCHEMBL29697210 | 0.87 | KDM4E (1.00) | KDM4EKMT2APIM1PDE4DMMP2 | |
| SCHEMBL29932233 | 0.86 | KDM4E (0.96) | KDM4EKMT2APIM1PDE4DMMP2 | |
| SCHEMBL28949889 | 0.86 | KDM4E (0.96) | KDM4EKMT2APIM1PDE4DMMP2 | |
| SCHEMBL27688602 | 0.86 | KDM4E (0.96) | KDM4EKMT2APIM1PDE4DMMP2 | |
| SCHEMBL28228512 | 0.86 | KDM4E (0.96) | KDM4EKMT2APIM1PDE4DMMP2 | |
| SCHEMBL7362665 | 0.85 | KMT2A (0.54) | KDM4EKMT2APIM1PDE4DMETAP2 | |
| SCHEMBL2059128 | 0.81 | KDM4E (0.87) | KDM4EKMT2APIM1PDE4DMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |