Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847651 | 0.90 | KDM4E (0.65) | KMT2AKDM4EPIM1PDE4DALDH1A1 | |
| SCHEMBL3761206 | 0.85 | KMT2A (0.52) | KMT2AKDM4EPIM1PDE4DALDH1A1 | |
| SCHEMBL7362663 | 0.85 | KDM4E (0.77) | KMT2AKDM4EPIM1PDE4DCA1 | |
| SCHEMBL4701058 | 0.83 | KDM4E (0.56) | KMT2AKDM4EPDE4DALDH1A1CA1 | |
| SCHEMBL3433145 | 0.82 | KMT2A (0.49) | KMT2AKDM4EPIM1PDE4DALDH1A1 | |
| SCHEMBL2950729 | 0.80 | ALDH1A1 (0.44) | KMT2AKDM4EPDE4DALDH1A1CA1 | |
| SCHEMBL4995737 | 0.75 | MAPK1 (0.50) | KMT2AKDM4EMEN1NPC1RAB9A | |
| SCHEMBL2118060 | 0.75 | CA1 (0.45) | KMT2AKDM4EPDE4DALDH1A1CA1 | |
| SCHEMBL23714070 | 0.75 | CYP1A2 (0.47) | KMT2AKDM4EPIM1ALDH1A1MEN1 | |
| SCHEMBL31429914 | 0.75 | KDM4E (0.48) | KMT2AKDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |