SCHEMBL7362843

SCHEMBL7362843

NCCOc1ccc2ccccc2c1Br

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1B P28222 2/20 0.64
MAPT P10636 4/20 0.50
MAPK1 P28482 2/20 0.50
KDM4E B2RXH2 1/20 0.50
RAB9A P51151 3/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
HPGD P15428 1/20 0.49
RXFP1 Q9HBX9 3/20 0.48
PRNP P04156 3/20 0.48
ALDH1A1 P00352 2/20 0.48
LMNA P02545 1/20 0.47
POLB P06746 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
TP53 P04637 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46
TSHR P16473 1/20 0.46
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7360142 0.98 HTR1B (0.62) HTR1BMAPTMAPK1KDM4ERAB9A
SCHEMBL4736696 0.84 MAPT (0.51) MAPTMAPK1KDM4ERAB9ASMN1; SMN2
SCHEMBL12370653 0.83 MAPT (0.50) HTR1BMAPTMAPK1KDM4ERAB9A
SCHEMBL28165209 0.83 MAPT (0.50) MAPTMAPK1KDM4ERAB9ASMN1; SMN2
SCHEMBL7362839 0.83 MAPT (0.50) MAPTMAPK1KDM4ERAB9ASMN1; SMN2
SCHEMBL14393504 0.81 GAA (0.61) HTR1BMAPTMAPK1RAB9ASMN1; SMN2
SCHEMBL12370651 0.80 MAPT (0.48) MAPTMAPK1KDM4ERAB9ASMN1; SMN2
SCHEMBL7362748 0.79 RAB9A (0.51) MAPTMAPK1RAB9ASMN1; SMN2HPGD
SCHEMBL26622001 0.79 RAB9A (0.55) MAPTMAPK1RAB9ASMN1; SMN2HPGD
SCHEMBL30825865 0.78 HTR1B (1.00) HTR1BMAPTKDM4ERAB9AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6307090-B1 OXALYL ENDCAPPED; CONTAINING A BIVALENT RADICAL OF PHOSPHOTYROSINE OR A PHOSPHOTYROSINE MIMETIC THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2001-10-23 US disclosed
EP-0846127-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY Novartis AG (CH) 1998-06-10 EP disclosed
WO-1997008193-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY NOVARTIS AG (CH) 1997-03-06 WO disclosed