Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364766 | 0.84 | CYP19A1 (0.56) | CYP19A1CYP11B1CYP11B2EGFRTNF | |
| SCHEMBL6799661 | 0.83 | ABCG2 (0.52) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL6797852 | 0.80 | MAPT (0.50) | MEN1KMT2AL3MBTL1FGFR1FGFR2 | |
| SCHEMBL6792428 | 0.77 | PDE5A (0.49) | MEN1KMT2AL3MBTL1FGFR1FGFR2 | |
| SCHEMBL6797321 | 0.76 | MAPT (0.55) | MEN1KMT2AL3MBTL1EGFRABCG2 | |
| SCHEMBL6803111 | 0.75 | MAPT (0.61) | MEN1KMT2AL3MBTL1ABCG2MAPT | |
| SCHEMBL6798323 | 0.75 | MAPT (0.54) | MEN1KMT2AL3MBTL1EGFRABCG2 | |
| SCHEMBL6790872 | 0.74 | MAPT (0.56) | MEN1KMT2AL3MBTL1ABCG2MAPT | |
| SCHEMBL7357488 | 0.74 | MAPT (0.56) | MEN1KMT2AL3MBTL1EGFRABCG2 | |
| SCHEMBL6795443 | 0.74 | MAPT (0.53) | MEN1KMT2AL3MBTL1EGFRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-B1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6117875-A | Pyrido (2,3-B) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0874845-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024355-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |