Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.52 |
| ▸ | PDE4A | P27815 | 9/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362976 | 1.00 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7365297 | 1.00 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7371994 | 0.92 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL3181116 | 0.84 | PDE4A (0.65) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8573448 | 0.84 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7372000 | 0.84 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7398709 | 0.83 | PDE4A (0.52) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7353707 | 0.83 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7371997 | 0.82 | PDE4A (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7371995 | 0.82 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007141-A1 | HETEROCYCLIC 3-PHENYLPYRROLIDIN-2-ONES, THEIR PREPARATION AND USE FOR THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING TUMOR NECROSIS FACTOR PRODUCTION | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | disclosed |