Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 5/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.52 |
| ▸ | WNT1 | P04628 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504335 | 1.00 | DYRK1A (0.64) | DYRK1AGSK3BRIPK1MEN1KMT2A | |
| SCHEMBL2086136 | 0.88 | DYRK1A (0.65) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 | |
| SCHEMBL2086924 | 0.88 | DYRK1A (0.65) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 | |
| SCHEMBL7364907 | 0.88 | DYRK1A (0.64) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 | |
| SCHEMBL2089886 | 0.88 | DYRK1A (0.64) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 | |
| SCHEMBL7506894 | 0.88 | DYRK1A (0.64) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 | |
| SCHEMBL2089883 | 0.88 | DYRK1A (0.64) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 | |
| SCHEMBL2087708 | 0.86 | HTR3A (0.68) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 | |
| SCHEMBL2087052 | 0.86 | HTR3A (0.68) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 | |
| SCHEMBL2087471 | 0.85 | DYRK1A (0.61) | DYRK1AGSK3BHTR3AHTR3ESLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498466-B1 | Indazole-3-carboxamide and -3-carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 2002-07-24 | — | — | EP | claimed |
| EP-0498466-A1 | Indazole-3-carboxamide and -3-carboxylic acid derivatives | BEECHAM GROUP PLC (GB) | 1992-08-12 | — | — | EP | claimed |
| EP-0200444-A2 | Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity | BEECHAM GROUP PLC (GB) | 1986-11-05 | — | — | EP | claimed |
| EP-0498466-B1 | Indazole-3-carboxamide and -3-carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 2002-07-24 | — | — | EP | disclosed |
| US-5034398-A | Analgesics | BEECHAM GROUP P.L.C. (GB) | 1991-07-23 | — | — | US | disclosed |
| US-4886808-A | Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis | BEECHAM GROUP P.L.C. (GB) | 1989-12-12 | — | — | US | disclosed |
| EP-0200444-A2 | Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity | BEECHAM GROUP PLC (GB) | 1986-11-05 | — | — | EP | disclosed |