Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 7/20 | 0.49 |
| ▸ | REN | P00797 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PEPD | P12955 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6783107 | 0.91 | ACE (0.57) | ACERENKDM4EF2LMNA | |
| SCHEMBL6783112 | 0.91 | ACE (0.57) | ACERENKDM4EF2LMNA | |
| SCHEMBL10173234 | 0.85 | ACE (0.55) | ACERENKDM4EF2LMNA | |
| SCHEMBL9362237 | 0.85 | ACE (0.55) | ACERENKDM4EF2LMNA | |
| SCHEMBL10173273 | 0.85 | ACE (0.55) | ACERENKDM4EF2LMNA | |
| SCHEMBL3470058 | 0.80 | ACE (0.56) | NPSR1ACEACE2ALDH1A1 | |
| SCHEMBL6437755 | 0.79 | DPP4 (0.69) | ACE | |
| SCHEMBL6437757 | 0.79 | DPP4 (0.69) | ACE | |
| SCHEMBL24668844 | 0.79 | ACE (0.52) | NPSR1ACERENKDM4EF2 | |
| SCHEMBL4001869 | 0.79 | ALDH1A1 (0.74) | NPSR1LMNAALDH1A1SMN1; SMN2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165508-A1 | ANTICANCER CALCIUM CHANNEL BLOCKERS | Gray, Lloyd S. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059882-A1 | ANTICANCER CALCIUM CHANNEL BLOCKERS | GRAY LLOYD S (US) | 2000-10-12 | — | — | WO | disclosed |