Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.65 |
| ▸ | CTSG | P08311 | 1/20 | 0.64 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429826 | 1.00 | ELANE (0.65) | ELANECTSGCMA1 | |
| SCHEMBL7363455 | 1.00 | ELANE (0.65) | ELANECTSGCMA1 | |
| SCHEMBL4287233 | 1.00 | ELANE (0.65) | ELANECTSGCMA1 | |
| SCHEMBL18880036 | 0.90 | ELANE (0.68) | ELANECTSGCMA1 | |
| SCHEMBL7310675 | 0.90 | ELANE (0.80) | ELANECTSGCMA1 | |
| SCHEMBL17378380 | 0.90 | ELANE (0.68) | ELANECTSGCMA1 | |
| SCHEMBL13924699 | 0.89 | ELANE (0.56) | ELANECTSG | |
| SCHEMBL18880040 | 0.88 | ELANE (0.66) | ELANECTSGCMA1 | |
| SCHEMBL22686717 | 0.88 | ELANE (0.69) | ELANECTSGCMA1 | |
| SCHEMBL20943172 | 0.88 | ELANE (0.69) | ELANECTSGCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037363-A | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 2000-03-14 | — | — | US | disclosed |
| US-6037363-A | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase | ZENECA LIMITED (GB) | 2000-03-14 | — | — | US | disclosed |
| EP-0743953-B1 | DIASTEREOMERIC PURE TRIFLUOROMETHYL KETONE PEPTIDE DERIVATIVES AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE | ZENECA LTD (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1995021855-A1 | DIASTEREOMERIC PURE TRIFLUOROMETHYL KETONE PEPTIDE DERIVATIVES AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE | ZENECA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |