SCHEMBL7363455

SCHEMBL7363455

COc1ccc(C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)C(C)C)cc1

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ELANE P08246 19/20 0.65
CTSG P08311 1/20 0.64
CMA1 P23946 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8429826 1.00 ELANE (0.65) ELANECTSGCMA1
SCHEMBL7363457 1.00 ELANE (0.65) ELANECTSGCMA1
SCHEMBL4287233 1.00 ELANE (0.65) ELANECTSGCMA1
SCHEMBL18880036 0.90 ELANE (0.68) ELANECTSGCMA1
SCHEMBL7310675 0.90 ELANE (0.80) ELANECTSGCMA1
SCHEMBL17378380 0.90 ELANE (0.68) ELANECTSGCMA1
SCHEMBL13924699 0.89 ELANE (0.56) ELANECTSG
SCHEMBL18880040 0.88 ELANE (0.66) ELANECTSGCMA1
SCHEMBL22686717 0.88 ELANE (0.69) ELANECTSGCMA1
SCHEMBL20943172 0.88 ELANE (0.69) ELANECTSGCMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116838-A1 NEOCARZILIN DERIVATIVES AS ANTIMETASTATIC AGENTS PURDUE RESEARCH FOUNDATION (US) 2026-04-30 US disclosed
US-12612631-B2 Small RNA medicament for prevention and treatment of inflammation-related diseases and combination thereof BEIJING BAISHIHEKANG PHARMACEUTICAL TECHNOLOGY (BSJPHARMA) CO., LTD (CN) 2026-04-28 US disclosed
EP-4004548-B1 METHODS OF TREATING AND DIAGNOSING LUNG CANCER YEDA RES & DEV (IL) 2026-01-14 EP disclosed
US-20250354993-A1 METHODS OF TREATING AND DIAGNOSING LUNG CANCER YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2025-11-20 US disclosed
EP-3713918-B1 SULFASALAZINE SALTS, PRODUCTION PROCESSES AND USES MEDAC GES FUER KLINISCHE SPEZIALPRAEPARATE MBH (DE) 2025-07-23 EP disclosed
US-20250223351-A1 Compounds MEDIMMUNE LTD (GB) 2025-07-10 US disclosed
US-20250197401-A1 PURINONE DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2025-06-19 US disclosed
EP-3960858-B1 SMALL RNA MEDICAMENT FOR PREVENTION AND TREATMENT OF INFLAMMATION-RELATED DISEASES AND COMBINATION THEREOF BEIJING BAISHIHEKANG PHARMACEUTICAL TECH BSJPHARMA CO LTD (CN) 2025-05-07 EP disclosed
US-12274706-B2 Pharmaceutical composition for oral administration containing sulfasalazine and/or a sulfasalazine organic salt, production process and use MEDAC GESELLSCHAFT FUER KLINISCHE (DE) 2025-04-15 US disclosed
EP-4509496-A2 SULFASALAZINE SALTS, PRODUCTION PROCESSES AND USES medac Gesellschaft für klinische Spezialpräparate mbH (DE) 2025-02-19 EP disclosed
EP-1919493-B1 USE OF SPECIFIC TRIFLUOROMETHYL KETONES FOR PREVENTING AND TREATING PANCREATITIS LERCH MARKUS M (DE) 2014-07-30 EP disclosed
US-20090042969-A1 Use of Specific Trifluoromethyl Ketones for Preventing and Treating Pancreatitis ERNST-MORITZ-ARNDT-UNIVERSITAT GREIFSWALD (DE) 2009-02-12 US disclosed
US-6037363-A Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase ZENECA LIMITED (GB) 2000-03-14 US disclosed
US-6037363-A Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase ZENECA LIMITED (GB) 2000-03-14 US disclosed
US-5907043-A Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase ZENECA LIMITED (GB) 1999-05-25 US disclosed
US-5907043-A Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase ZENECA LIMITED (GB) 1999-05-25 US disclosed
EP-0743953-B1 DIASTEREOMERIC PURE TRIFLUOROMETHYL KETONE PEPTIDE DERIVATIVES AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE ZENECA LTD (GB) 1998-12-02 EP disclosed
US-5739157-A Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase ZENECA LIMITED (GB) 1998-04-14 US disclosed
US-5739157-A Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase ZENECA LIMITED (GB) 1998-04-14 US disclosed
WO-1995021855-A1 DIASTEREOMERIC PURE TRIFLUOROMETHYL KETONE PEPTIDE DERIVATIVES AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE ZENECA LIMITED (GB) 1995-08-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042969-A1 Use of Specific Trifluoromethyl Ketones for Preventing and Treating Pancreatitis PNLIP, AMY2A, FABP2 ELANE 19/4885CTSG 164/4885CMA1 183/4885
US-12612631-B2 Small RNA medicament for prevention and treatment of inflammation-related diseases and combination thereof EIF2AK2, IL1A, IRF3 ELANE 541/4885CTSG 1633/4885CMA1 925/4885
US-20250197401-A1 PURINONE DERIVATIVE BTK, KIT, SYK ELANE 2331/4885CTSG 1394/4885CMA1 103/4885
US-20260116838-A1 NEOCARZILIN DERIVATIVES AS ANTIMETASTATIC AGENTS SLC75A1, SLC18A3, SLC8A1 ELANE 2086/4885CTSG 1421/4885CMA1 733/4885
US-12274706-B2 Pharmaceutical composition for oral administration containing sulfasalazine and/or a sulfasalazine organic salt, production process and use SI, SOST, SLC10A2 ELANE 1988/4885CTSG 1097/4885CMA1 186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.