Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 10/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355550 | 0.87 | RECQL (0.47) | KDM4ENAPRTTBXAS1FDPSCHRM1 | |
| SCHEMBL9301828 | 0.80 | CHRM1 (0.64) | KDM4ENAPRTTBXAS1FDPSCHRM1 | |
| SCHEMBL7830186 | 0.80 | CHRM1 (0.64) | KDM4ENAPRTTBXAS1FDPSCHRM1 | |
| SCHEMBL19031875 | 0.78 | KDM4E (0.51) | KDM4ENAPRTTBXAS1FDPSCHRM1 | |
| SCHEMBL6885074 | 0.77 | KDM4E (0.62) | KDM4ENAPRTTBXAS1FDPSCHRM1 | |
| SCHEMBL7384333 | 0.76 | CYP1A2 (0.62) | KDM4ENAPRTTBXAS1FDPSCPA1 | |
| SCHEMBL5174680 | 0.74 | KDM4E (0.63) | KDM4ENAPRTTBXAS1FDPSCHRM1 | |
| SCHEMBL1827062 | 0.74 | KDM4E (0.63) | KDM4ENAPRTTBXAS1FDPSCHRM1 | |
| SCHEMBL12238430 | 0.74 | KDM4E (0.63) | KDM4ENAPRTTBXAS1FDPSCHRM1 | |
| SCHEMBL30186102 | 0.74 | KDM4E (0.63) | KDM4ENAPRTTBXAS1FDPSCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369743-B1 | Heterocyclic amides | ZENECA LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| EP-0369743-A2 | Heterocyclic amides | ZENECA LIMITED (GB) | 1990-05-23 | — | — | EP | disclosed |