Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.56 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.56 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.56 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150297 | 0.89 | CACNA1B (0.71) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL28742846 | 0.87 | CACNA1B (0.65) | CACNA1B | |
| SCHEMBL10659839 | 0.86 | ADORA3 (0.55) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL27853207 | 0.85 | TSHR (0.56) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7434340 | 0.84 | ADORA3 (0.62) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL11783086 | 0.84 | GAA (0.59) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL3905675 | 0.84 | ADORA3 (0.83) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL11783074 | 0.83 | GAA (0.64) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10540800 | 0.83 | ADORA3 (0.60) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7267420 | 0.83 | CACNA1B (0.68) | CACNA1BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| EP-0541634-A1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |