Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351927 | 0.90 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7358687 | 0.89 | POLB (0.51) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL8590946 | 0.85 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| Acetic Acid SCHEMBL2459347 | 0.83 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11428703 | 0.82 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5047781 | 0.81 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7322576 | 0.81 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7325901 | 0.80 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30530004 | 0.79 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7363289 | 0.79 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |