Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7126111 | 0.89 | MAPT (0.40) | MAPTHSD17B10ALDH1A1NPC1RAB9A | |
| SCHEMBL7069160 | 0.88 | MAPT (0.44) | MAPTHSD17B10ALDH1A1NPC1RAB9A | |
| SCHEMBL7072413 | 0.85 | MAPT (0.43) | MAPTHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7067665 | 0.84 | TPSAB1 (0.36) | MAPTNPC1F9TPSAB1TPSD1 | |
| SCHEMBL7072410 | 0.83 | MAPT (0.43) | MAPTHSD17B10ALDH1A1NPC1RAB9A | |
| SCHEMBL7071781 | 0.82 | F10 (0.42) | MAPTALDH1A1NPC1TP53TPSAB1 | |
| SCHEMBL7068332 | 0.79 | F2 (0.40) | MAPTHSD17B10ALDH1A1NPC1RAB9A | |
| SCHEMBL7072722 | 0.78 | MAPT (0.38) | MAPTNPC1SMN1; SMN2F9TPSAB1 | |
| SCHEMBL7069757 | 0.78 | MAPT (0.52) | MAPTALDH1A1NPC1POLBTHRB | |
| SCHEMBL7069773 | 0.75 | F10 (0.41) | MAPTNPC1TP53TPSAB1TPSD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019382-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE, PARTICULARLY TRYPTASE, ACTIVITY | AXYS PHARMACEUTICALS, INC. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998045275-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE, PARTICULARLY TRYPTASE, ACTIVITY | AXYS PHARMACEUTICALS CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |