Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359405 | 0.79 | PDE4A (0.61) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7364896 | 0.78 | PDE4A (0.54) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7365106 | 0.77 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9169841 | 0.76 | PDE4A (0.58) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7363454 | 0.74 | PDE4A (0.74) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7363892 | 0.72 | PDE4A (0.71) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7365957 | 0.72 | PDE4A (0.85) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7363890 | 0.72 | PDE4A (0.61) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7364942 | 0.72 | PDE4A (1.00) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL8694738 | 0.71 | PDE4A (0.75) | PDE4APDE4DPDE4CPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |