Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370208 | 0.91 | PDE4A (0.53) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL8694519 | 0.86 | PDE4A (0.45) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7360445 | 0.85 | PDE4A (0.56) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9375515 | 0.84 | PDE4A (0.43) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7368033 | 0.84 | PIK3CD (0.50) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7370135 | 0.83 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7369501 | 0.82 | PDE4A (0.63) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7361119 | 0.81 | PDE4A (0.51) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7363454 | 0.81 | PDE4A (0.74) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL9376018 | 0.80 | PDE4A (0.55) | PDE4APDE4DPDE4CPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |