Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10438238 | 0.98 | IDO1 (0.56) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL726313 | 0.85 | IDO1 (0.59) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5319528 | 0.84 | IDO1 (0.47) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13739921 | 0.84 | CYP3A4 (0.48) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7231541 | 0.83 | IDO1 (0.57) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6601781 | 0.83 | IDO1 (0.57) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1132341 | 0.83 | IDO1 (0.57) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL15881145 | 0.82 | SIRT3 (0.49) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11802077 | 0.81 | CYP19A1 (0.56) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1239412 | 0.81 | IDO1 (0.54) | IDO1CYP3A4CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114249692-B | 2-imidazole benzamide active compound for preventing and treating wheat take-all and wheat stem basal rot | 河南农业大学 | 2024-01-30 | — | — | CN | claimed |
| WO-2014111871-A1 | 4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-07-24 | — | — | WO | claimed |
| EP-2691375-A1 | SUBSTITUTED BENZIMIDAZOLES | Bayer Intellectual Property GmbH (DE) | 2014-02-05 | — | — | EP | claimed |
| WO-2012130905-A1 | SUBSTITUTED BENZIMIDAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-04 | — | — | WO | claimed |
| CN-114249692-B | 2-imidazole benzamide active compound for preventing and treating wheat take-all and wheat stem basal rot | 河南农业大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-114249692-B | 2-imidazole benzamide active compound for preventing and treating wheat take-all and wheat stem basal rot | 河南农业大学 | 2024-01-30 | — | — | CN | disclosed |
| WO-2015055994-A1 | CYCLOPENTYLBENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PSYCHOTIC AND COGNITIVE DISORDERS | TAKEDA CAMBRIDGE LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |
| CN-1900080-A | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LTD (GB) | 2007-01-24 | — | — | CN | disclosed |
| CN-1269822-C | Inhibitors of kruenza protease and other cysteine proteases | AMURA THERAPEUTICS LTD (GB) | 2006-08-16 | — | — | CN | disclosed |
| WO-1996017630-A9 | SUBSTITUTED BENZAMIDES AND RADIOLIGAND ANALOGS AND METHODS OF USE | — | 1996-08-08 | — | — | WO | disclosed |
| WO-1996017630-A1 | SUBSTITUTED BENZAMIDES AND RADIOLIGAND ANALOGS AND METHODS OF USE | VANDERBILT UNIVERSITY (US) | 1996-06-13 | — | — | WO | disclosed |