Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | CPA1 | P15085 | 2/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.50 |
| ▸ | IL1RN | P18510 | 1/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440191 | 0.90 | KMT2A (0.52) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL7440200 | 0.90 | KMT2A (0.52) | MMEACECPA1ACE2MEN1 | |
| Hydrochloric Acid SCHEMBL7896063 | 0.89 | KMT2A (0.51) | MMEACECPA1ACE2MEN1 | |
| Hydrochloric Acid SCHEMBL7896068 | 0.89 | KMT2A (0.51) | MMEACECPA1ACE2MEN1 | |
| SCHEMBL7369252 | 0.89 | REN (0.53) | RENMMEACECPA1ACE2 | |
| SCHEMBL7405538 | 0.89 | REN (0.53) | RENMMEACECPA1ACE2 | |
| SCHEMBL8179352 | 0.88 | MME (0.56) | RENMMEACECPA1ACE2 | |
| SCHEMBL7408594 | 0.86 | REN (0.56) | RENMMEACECPA1ACE2 | |
| SCHEMBL7364989 | 0.86 | MME (0.56) | RENMMEACECPA1ACE2 | |
| SCHEMBL24206195 | 0.84 | MME (0.48) | RENMMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117841-A | USED TO TREAT STROKE, CEREBRAL ISCHEMIA, PAIN, HEAD TRAUMA OR EPILEPSY | WARNER-LAMBERT COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | disclosed |