Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | GAA | P10253 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.45 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369831 | 0.86 | APEX1 (0.55) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL9936524 | 0.84 | MEN1 (0.49) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL6102581 | 0.81 | KDM4E (1.00) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL30854920 | 0.81 | KDM4E (1.00) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL2003333 | 0.80 | KDM4E (0.75) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL1757962 | 0.78 | KDM4E (0.73) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL13401405 | 0.78 | KDM4E (0.73) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL3408821 | 0.78 | KDM4E (0.73) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL11338372 | 0.78 | KDM4E (0.73) | KDM4EGAAMAPTMEN1KMT2A | |
| SCHEMBL11352581 | 0.77 | HTR6 (0.62) | MEN1KMT2AL3MBTL1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |