Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.63 |
| ▸ | PDE4A | P27815 | 7/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372552 | 0.95 | PDE4D (0.58) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL4728938 | 0.85 | PDE4B (0.80) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL27472680 | 0.83 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL14282266 | 0.82 | PDE4B (0.63) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL2472801 | 0.82 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL30009845 | 0.82 | PDE4B (0.80) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL8343302 | 0.82 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL128167 | 0.82 | PDE4B (0.70) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL1028427 | 0.82 | PDE4B (0.80) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL9005494 | 0.81 | PDE4D (0.78) | PDE4DPDE4BPDE4APDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |