Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364785 | 1.00 | SIRT2 (0.49) | SIRT2SIRT1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7364788 | 1.00 | SIRT2 (0.49) | SIRT2SIRT1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6797400 | 0.93 | SIRT1 (0.56) | SIRT2SIRT1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6797393 | 0.93 | SIRT1 (0.56) | SIRT2SIRT1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6794745 | 0.87 | SIRT2 (0.49) | SIRT2SIRT1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6794751 | 0.87 | SIRT2 (0.49) | SIRT2SIRT1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7366930 | 0.86 | MAPT (0.41) | KMT2AKDM4ESMN1; SMN2MEN1HTT | |
| SCHEMBL7366927 | 0.86 | MAPT (0.41) | KMT2AKDM4ESMN1; SMN2MEN1HTT | |
| SCHEMBL7360885 | 0.85 | MAPT (0.45) | SIRT2SIRT1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7360882 | 0.85 | MAPT (0.45) | SIRT2SIRT1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-B1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| CN-1066732-C | Pyrido (2,3-b) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-06-06 | — | — | CN | disclosed |
| US-6117875-A | Pyrido (2,3-B) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| CN-1205702-A | Pyrido (2,3-b) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-20 | — | — | CN | disclosed |
| EP-0874845-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024355-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |