Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 3/20 | 0.50 |
| ▸ | AKT2 | P31751 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL540893 | 0.85 | MAPK1 (0.59) | PDE10ATP53MAPTMEN1KMT2A | |
| SCHEMBL13052922 | 0.83 | PDE10A (0.56) | PDE10ATP53MAPTMEN1KMT2A | |
| SCHEMBL17077773 | 0.82 | MEN1 (0.60) | PDE10ATP53MAPTMEN1KMT2A | |
| SCHEMBL9726854 | 0.81 | PDE4B (0.55) | PDE10ATP53MAPTMEN1KMT2A | |
| SCHEMBL13052928 | 0.80 | TP53 (0.51) | PDE10ATP53MAPTMEN1KMT2A | |
| SCHEMBL28100866 | 0.79 | MEN1 (0.62) | PDE10ATP53MAPTMEN1KMT2A | |
| SCHEMBL18355591 | 0.78 | TP53 (0.49) | PDE10ATP53MAPTMEN1KMT2A | |
| SCHEMBL18355574 | 0.78 | MEN1 (0.58) | PDE10ATP53MAPTMEN1KMT2A | |
| Bromide SCHEMBL18614592 | 0.77 | MEN1 (0.57) | PDE10ATP53MAPTMEN1KMT2A | |
| SCHEMBL12628707 | 0.76 | PDE10A (0.50) | PDE10ATP53MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| CN-1094028-A | Selective PDE enzyme (IV) inhibitor catechol diether class | PFIZER (US) | 1994-10-26 | — | — | CN | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |